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Module Specifications.

Current Academic Year 2024 - 2025

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Date posted: September 2024

No Banner module data is available

Module Title
Module Code (ITS)
Faculty School
Module Co-ordinatorSemester 1: Janosch Heller
Semester 2: Janosch Heller
Autumn: Anne Parle-McDermott
Module TeachersPaula Meleady
Anne Parle-McDermott
Naomi Walsh
Denise Harold
Linda Holland
Janosch Heller
NFQ level 8 Credit Rating
Pre-requisite Not Available
Co-requisite Not Available
Compatibles Not Available
Incompatibles Not Available
Repeat examination
Array
Description

To develop a good understanding of the biology of bacteriophages and plasmids. To teach the basis of techniques used in the manipulation of DNA/RNA and to provide a theoretical background that would enable students to learn the skills involved in nucleic acid manipulation. To develop an appreciation and understanding of the complexity of gene expression and its control, with an emphasis on eukaryotic systems. To give an overview of the content of Eukaryotic genomes and their functionality.

Learning Outcomes

1. Design and understand recombinant DNA cloning strategies and other relevant molecular biological methodologies useful in the investigation of nucleic acids.
2. Select the appropriate vector system for application in genetic analysis
3. Analyse genome sequences to gain an understanding of gene organisation and function of the encoded information- a focus on the gene itself as a functional unit
4. Design an experimental approach to monitor the expression of genes using RNA analysis
5. Gain knowledge and understanding of the complexity of Eukaryotic Gene Expression control.



Workload Full-time hours per semester
Type Hours Description
Tutorial12No Description
Lecture12No Description
Independent Study97Reading recommended text books and working through recorded lectures.
Assignment Completion4No Description
Total Workload: 125

All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml

Indicative Content and Learning Activities

Recombinant DNA technology

- restriction enzymes, joining DNA molecules. DNA amplification, the polymerase chain reaction. Vectors for gene cloningPlasmids, introduction to plasmids

- structure, high and low copy number, different forms, plasmid encoded phenotypes.Replication of plasmids

DNA sequencing methodologies.

Assessment Breakdown
Continuous Assessment% Examination Weight%
Course Work Breakdown
TypeDescription% of totalAssessment Date
Loop Quiz3 Loop quizzes (each worth 3.33%) in weeks 3, 4, 5 covering first half of BE30110%Other
Loop Quiz3 Loop quizzes (each worth 3.33%) in weeks 9, 10, 11 covering second half of BE30110%Other
Indicative Reading List

  • Jeremy W. Dale, Simon Park: 0, Molecular genetics of bacteria, 0470850841
  • Richard J. Reece: 0, Analysis of genes and genomes, 0470843799
  • T. A. Brown: 0, Genetics, 0412447304
  • Lewin: 0, GENES XII,
  • Strachan and Read: 0, Human Molecular Genetics,
  • Mumtaz Anwar, Riyaz Ahmad Rather, Zeenat Farooq: 0, Fundamentals and Advances in Medical Biotechnology,
  • Kakoli Bose: 0, Textbook on Cloning, Expression and Purification of Recombinant Proteins,
Other Resources

None

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