Module: Downstream Processing

Module Specifications.

Current Academic Year 2024 - 2025

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Date posted: September 2024

Module Title	Downstream Processing
Module Code	BE321 (ITS) / BTE1010 (Banner)
Faculty	Science & Health	School	Biotechnology
Module Co-ordinator	David Collins
Module Teachers	Denise Harold, Paul Cahill, Paula Meleady
NFQ level	8	Credit Rating	5
Pre-requisite	Not Available
Co-requisite	Not Available
Compatibles	Not Available
Incompatibles	Not Available

Repeat examination
Similar paper as to EOT exam.

Description

This module introduces students to various unit operations in downstream bioprocessing with a focus on chromatography & filtration

Learning Outcomes

1. Formulate and solve design and analysis equations for concentration processes including evaporation and ultrafiltration.
2. Formulate and solve design and analysis equations for purification processes including diafiltration and liquid-liquid extraction.
3. Formulate and solve design and analysis equations for high resolution purifications including adsorption, chromatography and crystallisation.
4. Understand the mechanisms underlying liquid chromatography.
5. Understand how each mode of chromatography can be applied in the context of different analyte chemistry and stationary phase functionality.
6. Understand the complexity of bioseparations and how complex biomolecules can be characterised through hyphenated chromatography modes such as LC-MS.

*Type*	*Hours*	*Description*
Workload	Full-time hours per semester
Tutorial	24	Directed and active learning
Independent Study	101	Study and problem solving
Total Workload: 125

All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml

Indicative Content and Learning Activities

Evaporation

Ultrafiltration

Liquid-liquid extraction

Diafiltration

Adsorption

Chromatography

Crystallisation

Assessment Breakdown
Continuous Assessment	30%	Examination Weight	70%

Type	Description	% of total	Assessment Date
Course Work Breakdown
Assignment	Problem set: UF/DF	7%	n/a
In Class Test	UF/DF	7%	n/a
Loop Exam	Chromatography	15%	n/a

Reassessment Requirement Type
Resit arrangements are explained by the following categories: Resit category 1: A resit is available for both* components of the module. Resit category 2: No resit is available for a 100% continuous assessment module. Resit category 3: No resit is available for the continuous assessment component where there is a continuous assessment and examination element.
* ‘Both’ is used in the context of the module having a Continuous Assessment/Examination split; where the module is 100% continuous assessment, there will also be a resit of the assessment
This module is category 1

Indicative Reading List

Other Resources

None