Module: Bioreaction Engineering

Module Specifications..

Current Academic Year 2023 - 2024

Please note that this information is subject to change.

Module Title	Bioreaction Engineering
Module Code	BE420
School	School of Biotechnology
Module Co-ordinator	Semester 1: Vijai Kumar Gupta Semester 2: Vijai Kumar Gupta Autumn: Vijai Kumar Gupta
Module Teachers	Paula Meleady Brian Freeland Denise Harold David Collins Vijai Kumar Gupta
NFQ level	8	Credit Rating	7.5
Pre-requisite	None
Co-requisite	None
Compatibles	None
Incompatibles	None

None

Description

This module provides the student with an introduction to chemical, biochemical and microbial kinetics as well as the design and analysis of batch, fed-batch and continuous bioreactors.

Learning Outcomes

1. To understand the concept of a reaction rate for chemical, biochemical and microbial reactions
2. To be able to formulate overall and solute balances for batch bioreactors
3. To be able to formulate the solute and overall balances for fed-batch bioreactors
4. To be able to formulate the solute balances for continuous stirred tank reactors.
5. To be able to write computer code to simulation the performance of batch, fed-batch and continuous bioreactor performance.
6. To have knowledge and understanding of novel bioreactor conflations

*Type*	*Hours*	*Description*
Workload	Full-time hours per semester
Lecture	36	Lectures and tutorials
Independent Study	151.5	Study and problem-solving
Total Workload: 187.5

All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml

Indicative Content and Learning Activities

Principles of chemical and biochemical kinetics
Rate equations; kinetic data analysis; 1st and second order reaction order reactions; complex reaction; enzyme-catalysed reactions; inhibition;

Principles of microbial kinetics
Monod kinetics; the yield coefficient; cell death; cell maintenance; product formation;

Modelling of microbial growth in batch bioreactors
Formulation of cell and substrate balances in batch bioreactors; Exact solution of monod kinetics; simulation of cell growth using Berkeley Madonna and complex kinetics

Modelling of fed-batch bioreactors
The crabtree effect; formulation of solute balances in fed-batch systems; simulation of fed-batch bioreactors using Berkeley Madonna; operation of fed-batch bioreactors with exponential feed

Continuous bioreactors
Formulation of solute balances cell growth in a continuous stirred tank bioreactor; perfect mixing; dilution rate; washout; recycle; modelling of non-perfectly mixed CSTBs; plug-flow bioreactors; axial dispersion; tanks in series; simulation of tanks in series models.

Novel Bioreactor configurations
Packed bed bioreactors; airlift loop bioreactors; bubble column bioreactors

Assessment Breakdown
Continuous Assessment	60%	Examination Weight	40%

Type	Description	% of total	Assessment Date
Course Work Breakdown
Assignment	n/a	60%	n/a
Written Exam	n/a	40%	n/a

Reassessment Requirement Type
Resit arrangements are explained by the following categories; 1 = A resit is available for all components of the module 2 = No resit is available for 100% continuous assessment module 3 = No resit is available for the continuous assessment component
This module is category 1

Indicative Reading List

Other Resources

None

Programme or List of Programmes

BT	BSc in Biotechnology

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