Module: Immunology and Immunoanalysis

Module Specifications..

Current Academic Year 2023 - 2024

Please note that this information is subject to change.

Module Title	Immunology and Immunoanalysis
Module Code	BE433
School	School of Biotechnology
Module Co-ordinator	Semester 1: Christine Loscher Semester 2: Christine Loscher Autumn: Christine Loscher
Module Teachers	Paul Cahill Paula Meleady Christine Loscher Denise Harold Michael Freeley Linda Holland
NFQ level	8	Credit Rating	5
Pre-requisite	None
Co-requisite	None
Compatibles	None
Incompatibles	None

None

Description

This purpose of this module is to provide a detailed understanding of the theory and applications of advanced aspects of immunology. Students will be given an in depth insight into the advantages and limitations of immunoanalytical approaches in clinical, industrial and research situations.

Learning Outcomes

1. Explain the molecular factors that confer immunogenicity to antigens
2. Describe in detail the cellular components involved generating immunity
3. Discuss in detail the methods used to produce antibodies and their appropriate applications
4. Discuss how antibody-based therapy can be used to treat human disease
5. Describe aspects of immunoanalysis including cytometry, immuno-cytochemistry, sensors and antibody-based targeting of ligands
6. Outline the importance of assay validation and research ethics

*Type*	*Hours*	*Description*
Workload	Full-time hours per semester
Lecture	24	No Description
Seminars	2	No Description
Tutorial	4	No Description
Independent Study	95	No Description
Total Workload: 125

All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml

Indicative Content and Learning Activities

Immunology
The Process of antibody production at the cellular level; Intrinsic and extrinsic factors that influence antigenicity; Detailed account of B-cell stimulation; Antigen processing within the B-cell; The function and structure of the major histocompatibility antigens (MHC); The interaction of B-cells and T-cells; Genetic control of the immune response; Latest advances in understanding self, and non-self immune responses.

Immunoanalysis
Methods of antibody production (in detail) including polyclonal, monoclonal, bifunctional, multifunctional, genetic methods and production of antibody-derived fragments; Genetics of antibody production and phage display; Reshaped, chimaeric and human antibodies-production and applications; Use of antibodies in cancer including diagnosis,imaging and treatment; Production and application of conjugates used for the generation of antibodies and in immunoanalysis, Detailed account of immunocytochemistry and its applications;Introduction to next generation diagnostic devices.

Assessment Breakdown
Continuous Assessment	100%	Examination Weight	0%

Type	Description	% of total	Assessment Date
Course Work Breakdown

Reassessment Requirement Type
Resit arrangements are explained by the following categories; 1 = A resit is available for all components of the module 2 = No resit is available for 100% continuous assessment module 3 = No resit is available for the continuous assessment component
This module is category 1

Indicative Reading List

Ivan M. Roitt, Seamus J. Martin, Peter J. Delves, Dennis Burton,: 0, Roitt's Essential Immunology, 978-1-4051-3603-7
Kenneth M. Murphy, Paul Travers, Mark Walport: 2008, Janeway's immunobiology, Garland Science, New York, 978-0-8153-4123-9

Other Resources

None

Programme or List of Programmes

AFU	Age Friendly University Programme
BSSA	Study Abroad (DCU Business School)
BSSAO	Study Abroad (DCU Business School)
BT	BSc in Biotechnology
GCB	BSc in Genetics & Cell Biology
HMSA	Study Abroad (Humanities & Soc Science)
HMSAO	Study Abroad (Humanities & Soc Science)
IESA	Study Abroad (Institute of Education)
IESAO	Study Abroad (Institute of Education)
SHSA	Study Abroad (Science & Health)
SHSAO	Study Abroad (Science & Health)

Date of Last Revision

18-FEB-10

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