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Module Specifications..

Current Academic Year 2023 - 2024

Please note that this information is subject to change.

Module Title Formulation & Delivery of Biopharmaceuticals
Module Code BE486
School School of Biotechnology
Module Co-ordinatorSemester 1: Denise Harold
Semester 2: Denise Harold
Autumn: Denise Harold
Module TeachersPaula Meleady
Dermot Walls
Denise Harold
Linda Holland
NFQ level 8 Credit Rating 5
Pre-requisite None
Co-requisite None
Compatibles None
Incompatibles None

The aim of this module is to provide students with a critical overview of the challenges in administering biopharmaceuticals and strategies for overcoming the main delivery barriers. State of the art concepts for successful formulation and delivery of therapeutic peptides, proteins, nucleic acid-based drugs and vaccines will be described.

Learning Outcomes

1. List the major challenges in delivery of Biopharmaceuticals and explain why advanced delivery systems are needed
2. Describe how protein and peptide injectables may be chemically modified for improved delivery
3. Critically discuss novel non-injectable formulation approaches of peptide and protein drugs
4. Cite clinical trials using chemical and viral vectors for delivery of nucleic acids.
5. Evaluate commercial feasibility of lipid nanoparticles and polymer-based delivery systems for achieving real clinical applications.
6. Explain the role of freeze-drying technology in drug delivery systems

Workload Full-time hours per semester
Type Hours Description
Fieldwork16Asynchronous and synchronous classes and tutorials
Directed learning109Directed learning
Total Workload: 125

All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml

Indicative Content and Learning Activities

Novel formulation and delivery approaches for peptide and protein injectables

Novel non-injectable formulation approaches of peptides and proteins

Chemical vectors and Viral technology for delivery of nucleic acids

Polymer-Based delivery systems for oral and pulmonary delivery of peptides/proteins/nucleic acids. Role of Freeze drying technology in oral delivery systems.

Assessment Breakdown
Continuous Assessment0% Examination Weight100%
Course Work Breakdown
TypeDescription% of totalAssessment Date
Loop ExamWritten Continual assessment on Loop platform100%n/a
Reassessment Requirement Type
Resit arrangements are explained by the following categories;
1 = A resit is available for all components of the module
2 = No resit is available for 100% continuous assessment module
3 = No resit is available for the continuous assessment component
This module is category 1
Indicative Reading List

  • Sindelar, Robert D., editor; Meibohm, Bernd, editor; Crommelin, D. J. A. (Daan J. A) editor: 2013, Pharmaceutical biotechnology: fundamentals and applications, 4, New York: Informa Healthcare, 978-1-4614-64
  • edited by Michael E. Aulton and Kevin M.G. Taylor.: 2013, Aulton's pharmaceutics: the design and manufacture of medicines, 4, Philadelphia; Churchill Livingstone/Elsevier, 0702042900,
  • Lene Jorgensen (Editor), Hanne Morck Nielson (Co-Editor): 2009, Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines, 978-0-470-723
Other Resources

Programme or List of Programmes
AFUAge Friendly University Programme
BTBSc in Biotechnology
GCBBSc in Genetics & Cell Biology
SHSAStudy Abroad (Science & Health)
SHSAOStudy Abroad (Science & Health)
SMPSCSingle Module Prof. Science and Health

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