Module Specifications..
Current Academic Year 2023 - 2024
Please note that this information is subject to change.
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Description Module Aims: Precision Medicine 1 will focus on how advances in our understanding of cancer biology, together with advances in molecular diagnostics and targeted therapeutics, have revolutionised the treatment and outcome of cancer by tailoring treatments to the individual patient. Students will initially develop an understanding of the molecular, cellular and environmental basis of cancer. They will subsequently learn how through Precision Medicine, the treatment of several cancers has shifted away from the “One-Size-Fits-All” approach of treatment to a focused and tailored strategy based on the molecular profile of a patient’s tumour. The module will also focus on the critical importance of predictive diagnostic assays (Companion Diagnostics, Complimentary Diagnostics and Laboratory-Developed Tests) and prognostic diagnostic assays in Precision Medicine, as well as emerging role of diagnostics in the drug development process. Students will therefore develop an understanding of the theory and practice of Precision Medicine in oncology and how this knowledge has been translated into improved outcomes for cancer patients. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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Learning Outcomes 1. Demonstrate a range of standard and specialist knowledge of the genetic, molecular, cellular and environmental basis of cancer. 2. Using specific examples, critically appraise the milestones that led to the development of targeted therapeutics and diagnostics for the treatment of several cancers, including target identification/evaluation in pre-clinical models and the pivotal human clinical trials that led to their regulatory approval. 3. Critically evaluate the role of biomarkers in cancer screening, diagnosis, stratification of patients for therapy, monitoring of response to therapy and patient prognosis. 4. Demonstrate a systematic understanding of knowledge of the various types of in-vitro diagnostic assays that are used in Precision Medicine (including Companion Diagnostics, Complimentary Diagnostics and Laboratory-Developed Tests) and be able to distinguish between them. 5. Critically appraise how diagnostics have been integrated into the drug development process (drug-diagnostic co-development), and by highlighting several case studies, the challenges in implementing this co-development. 6. Demonstrate a specialist knowledge of the critical issues remaining to identify, classify and treat cancer more effectively and more efficiently. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml |
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Indicative Content and Learning Activities
Precision Medicine 1: Targeted Therapeutics and Diagnostics for CancerIntroduction to Precision Medicine; Introduction to Cancer; Clinical Trials in the Precision Medicine era; Companion Diagnostics, Complimentary Diagnostics and Laboratory-Developed Tests; Precision Medicine for Breast Cancer; Precision Medicine for Chronic Myeloid Leukaemia; Precision Medicine for Melanoma; Precision Medicine Immunotherapies for Cancer; Precision Medicine for Lung Cancer; Precision Medicine for Colorectal Cancer; Looking ahead and Future Challenges | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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Indicative Reading List | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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Other Resources None | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Programme or List of Programmes
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