Module: Bio-organic and Pharmaceutical Chemistry

Module Specifications..

Current Academic Year 2023 - 2024

Please note that this information is subject to change.

Module Title	Bio-organic and Pharmaceutical Chemistry
Module Code	CS206
School	School of Chemical Sciences
Module Co-ordinator	Semester 1: Nessan Kerrigan Semester 2: Nessan Kerrigan Autumn: Nessan Kerrigan
Module Teachers	Nessan Kerrigan Silvia Giordani Hasim Ibrahim
NFQ level	8	Credit Rating	5
Pre-requisite	None
Co-requisite	None
Compatibles	None
Incompatibles	None

Repeat examination
Array

Description

Bio-organic component: This aims to introduce the student to the three major classes of compound which come under the heading of bio-organic molecules: carbohydrates, proteins and nucleic acids. Pharmacology component: This aims to give a basic introduction to pharmacology and to give an overview of the actions of the major drug classes: anti-infectives, cardiovascular drugs, anticancer drugs and drugs that affect the central nervous system.

Learning Outcomes

1. Describe the structure and role of carbohydrates, amino acids, proteins and nucleic acids
2. Define fundamental pharmacological parameters
3. Relate drug structure and pharmacological action.
4. Give mode of action of major drug classes.

*Type*	*Hours*	*Description*
Workload	Full-time hours per semester
Lecture	36	No Description
Independent Study	89	No Description
Total Workload: 125

All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml

Indicative Content and Learning Activities

Pharmacology:
Introduction to pharmacology, commonly prescribed drugs, drug nomenclature, mechanisms of drug action, dose-response relationship. Agonists, antagonists. Receptor models. ED50. Therapeutic Index. Drug Administration. Drug Metabolism. ADME, Ideal drug.

Pharmaceuticals:
Major structural types, classification of the mode of action of drugs. Sources of drugs. Drug development and production. Antiinfectives: antibacterials and antivirals. Stereochemistry and biological activity. Pharmacokinetics and drug metabolism. Examples of phase I and phase II metabolic reactions according to functional groups. Cancer chemotherapy. Drugs affecting the CNS: hypnotics, sedatives, tranquilisers, antidepressants, analgesics, general anaesthetics. Cardiovascular drugs.

Bio-organic:
Carbohydrates: introduction to carbohydrates. Monosaccharides (in particular the family of D-hexoses): Kiliani-Fischer ascent and other reactions, mutarotation and configurations of glucose, Fisher projections, Haworth projections and skeletal structures. Disaccharides, oligosaccharides, polysaccharides Proteins: Amino acids: isoelectric point, synthesis, protection/deprotection, coupling reactions. Protein sequencing. Structure of proteins. Enzymes. Nucleic acids: Nucleotides, nucleosides and base pairs. Linkages and synthesis. Secondary structure, double helix. DNA, RNA role in body. Sequencing of DNA.

Assessment Breakdown
Continuous Assessment	0%	Examination Weight	100%

Type	Description	% of total	Assessment Date
Course Work Breakdown

Reassessment Requirement Type
Resit arrangements are explained by the following categories; 1 = A resit is available for all components of the module 2 = No resit is available for 100% continuous assessment module 3 = No resit is available for the continuous assessment component
This module is category 1

Indicative Reading List

Gareth Thomas: 2007, Medicinal chemistry, Chichester ; John Wiley, 0470025980
0: Any organic chemistry text book that covers bio-organic chemistry (e.g. Organic Chemistry by McMurry or by Solomons, several copies in DCU library),

Other Resources

None

Programme or List of Programmes

AC	BSc in Chemical and Pharmaceutical Sc.
AI	Chemistry with Artificial Intelligence
BSSA	Study Abroad (DCU Business School)
BSSAO	Study Abroad (DCU Business School)
GCB	BSc in Genetics & Cell Biology
HMSA	Study Abroad (Humanities & Soc Science)
HMSAO	Study Abroad (Humanities & Soc Science)
IESA	Study Abroad (Institute of Education)
IESAO	Study Abroad (Institute of Education)
SHSA	Study Abroad (Science & Health)
SHSAO	Study Abroad (Science & Health)

Date of Last Revision

04-JUN-09

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