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Module Specifications.

Current Academic Year 2024 - 2025

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Date posted: September 2024

Module Title Bio-organic & Pharmaceutical Chemistry
Module Code CS206 (ITS) / CHM1012 (Banner)
Faculty Science & Health School Chemical Sciences
Module Co-ordinatorSilvia Giordani
Module TeachersNessan Kerrigan
NFQ level 8 Credit Rating 5
Pre-requisite Not Available
Co-requisite Not Available
Compatibles Not Available
Incompatibles Not Available
Repeat examination
Array
Description

Bio-organic component: This aims to introduce the student to the three major classes of compound which come under the heading of bio-organic molecules: carbohydrates, proteins and nucleic acids. Pharmacology component: This aims to give a basic introduction to pharmacology and to give an overview of the actions of the major drug classes: anti-infectives, cardiovascular drugs, anticancer drugs and drugs that affect the central nervous system.

Learning Outcomes

1. Describe the structure and role of carbohydrates, amino acids, proteins and nucleic acids
2. Define fundamental pharmacological parameters
3. Relate drug structure and pharmacological action.
4. Give mode of action of major drug classes.



Workload Full-time hours per semester
Type Hours Description
Lecture36No Description
Independent Study89No Description
Total Workload: 125

All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml

Indicative Content and Learning Activities

Pharmacology:
Introduction to pharmacology, commonly prescribed drugs, drug nomenclature, mechanisms of drug action, dose-response relationship. Agonists, antagonists. Receptor models. ED50. Therapeutic Index. Drug Administration. Drug Metabolism. ADME, Ideal drug.

Pharmaceuticals:
Major structural types, classification of the mode of action of drugs. Sources of drugs. Drug development and production. Antiinfectives: antibacterials and antivirals. Stereochemistry and biological activity. Pharmacokinetics and drug metabolism. Examples of phase I and phase II metabolic reactions according to functional groups. Cancer chemotherapy. Drugs affecting the CNS: hypnotics, sedatives, tranquilisers, antidepressants, analgesics, general anaesthetics. Cardiovascular drugs.

Bio-organic:
Carbohydrates: introduction to carbohydrates. Monosaccharides (in particular the family of D-hexoses): Kiliani-Fischer ascent and other reactions, mutarotation and configurations of glucose, Fisher projections, Haworth projections and skeletal structures. Disaccharides, oligosaccharides, polysaccharides Proteins: Amino acids: isoelectric point, synthesis, protection/deprotection, coupling reactions. Protein sequencing. Structure of proteins. Enzymes. Nucleic acids: Nucleotides, nucleosides and base pairs. Linkages and synthesis. Secondary structure, double helix. DNA, RNA role in body. Sequencing of DNA.

Assessment Breakdown
Continuous Assessment0% Examination Weight100%
Course Work Breakdown
TypeDescription% of totalAssessment Date
Reassessment Requirement Type
Resit arrangements are explained by the following categories:
Resit category 1: A resit is available for both* components of the module.
Resit category 2: No resit is available for a 100% continuous assessment module.
Resit category 3: No resit is available for the continuous assessment component where there is a continuous assessment and examination element.
* ‘Both’ is used in the context of the module having a Continuous Assessment/Examination split; where the module is 100% continuous assessment, there will also be a resit of the assessment
This module is category 1
Indicative Reading List

  • Gareth Thomas: 2007, Medicinal chemistry, Chichester ; John Wiley, 0470025980
  • 0: Any organic chemistry text book that covers bio-organic chemistry (e.g. Organic Chemistry by McMurry or by Solomons, several copies in DCU library),
Other Resources

None

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