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Module Specifications.

Current Academic Year 2024 - 2025

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Date posted: September 2024

No Banner module data is available

Module Title
Module Code (ITS)
Faculty School
Module Co-ordinatorSemester 1: Andrew Kellett
Semester 2: Andrew Kellett
Autumn: Andrew Kellett
Module TeachersKieran Nolan
Andrew Kellett
Anthony Reilly
NFQ level 8 Credit Rating
Pre-requisite Not Available
Co-requisite Not Available
Compatibles Not Available
Incompatibles Not Available
None
Description

Students will be introduced to the concepts of drug design and development including the use of computational modelling. Concepts related to both drug delivery, pro-drugs and hybrid drug molecules are also described. Advanced topics relating to modern drug development will also be covered with emphasis on drug design, solid-form development, clinical trials and final marketing using specific drug examples from the last 15 years.

Learning Outcomes

1. Understand the principles of radiopharaceutical design and MRI contrast agents
2. Understand the principles of nucleic acid drugs and antisense therapeutics
3. Prodrug design and applications
4. Introduction to drug delivery
5. Drug design including fragment approaches, QSAR and 3D QSAR with specific examples.



Workload Full-time hours per semester
Type Hours Description
Lecture24Lectures
Directed learning101Independent study and learning
Total Workload: 125

All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml

Indicative Content and Learning Activities

Pharmaceutical solid form development
Polymorphism, salts, hydrates, co-crystals; Solid-form risk assessment, solid-form properties regulation of solid forms (ICH 6 & 9); Experimental and computational screening for solid forms, case studies.

Computational chemistry in drug development
Key computational approaches for modelling molecules (ab initio, force fields etc.); conformational analysis of APIs; basic principles of docking.

Radiopharmaceuticals and contrast agents
Metal complexes in disease diagnostics, radiopharmaceuticals, magnetic resonance imaging, SPECT, PET, tracer design

Nucleic acid drugs
Antisense therapeutics, gene editing, nucleic acid chemistry, hybrid nucleic acid drugs, nucleic acid chemistry

Assessment Breakdown
Continuous Assessment% Examination Weight%
Course Work Breakdown
TypeDescription% of totalAssessment Date
Indicative Reading List

  • 0: As directed in course, 297227
  • 2017: Developing Solid Oral Dosage Forms, E-book, Part I, Chapters 1-4, Elsevier, 297228
  • 2017: An introduction to medicinal chemistry, 6th, Oxford University Press,
Other Resources

None

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