Module: Advanced Medicinal Chemistry

Module Specifications..

Current Academic Year 2023 - 2024

Please note that this information is subject to change.

Module Title	Advanced Medicinal Chemistry
Module Code	CS414
School	School of Chemical Sciences
Module Co-ordinator	Semester 1: Andrew Kellett Semester 2: Andrew Kellett Autumn: Andrew Kellett
Module Teachers	Kieran Nolan Andrew Kellett Anthony Reilly
NFQ level	8	Credit Rating	5
Pre-requisite	None
Co-requisite	None
Compatibles	None
Incompatibles	None

None

Description

Students will be introduced to the concepts of drug design and development including the use of computational modelling. Concepts related to both drug delivery, pro-drugs and hybrid drug molecules are also described. Advanced topics relating to modern drug development will also be covered with emphasis on drug design, solid-form development, clinical trials and final marketing using specific drug examples from the last 15 years.

Learning Outcomes

1. Understand the importance and role of pharmaceutical solid forms in modern drug development.
2. Understand different approaches to using computer modelling in drug design and development.
3. Understand the principles of radiopharaceutical design and MRI contrast agents
4. Understand the principles of nucleic acid drugs and antisense therapeutics

*Type*	*Hours*	*Description*
Workload	Full-time hours per semester
Lecture	24	Lectures
Directed learning	101	Independent study and learning
Total Workload: 125

All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml

Indicative Content and Learning Activities

Pharmaceutical solid form development
Polymorphism, salts, hydrates, co-crystals; Solid-form risk assessment, solid-form properties regulation of solid forms (ICH 6 & 9); Experimental and computational screening for solid forms, case studies.

Computational chemistry in drug development
Key computational approaches for modelling molecules (ab initio, force fields etc.); conformational analysis of APIs; basic principles of docking.

Radiopharmaceuticals and contrast agents
Metal complexes in disease diagnostics, radiopharmaceuticals, magnetic resonance imaging, SPECT, PET, tracer design

Nucleic acid drugs
Antisense therapeutics, gene editing, nucleic acid chemistry, hybrid nucleic acid drugs, nucleic acid chemistry

Assessment Breakdown
Continuous Assessment	100%	Examination Weight	0%

Type	Description	% of total	Assessment Date
Course Work Breakdown

Reassessment Requirement Type
Resit arrangements are explained by the following categories; 1 = A resit is available for all components of the module 2 = No resit is available for 100% continuous assessment module 3 = No resit is available for the continuous assessment component
This module is category 1

Indicative Reading List

0: As directed in course, 185355
2017: Developing Solid Oral Dosage Forms, E-book, Part I, Chapters 1-4, Elsevier, 185356
2017: An introduction to medicinal chemistry, 6th, Oxford University Press,

Other Resources

None

Programme or List of Programmes

AC	BSc in Chemical and Pharmaceutical Sc.
AFU	Age Friendly University Programme
BSSA	Study Abroad (DCU Business School)
BSSAO	Study Abroad (DCU Business School)
HMSA	Study Abroad (Humanities & Soc Science)
HMSAO	Study Abroad (Humanities & Soc Science)
IESA	Study Abroad (Institute of Education)
IESAO	Study Abroad (Institute of Education)
SHSA	Study Abroad (Science & Health)
SHSAO	Study Abroad (Science & Health)
SMPSC	Single Module Prof. Science and Health

Date of Last Revision

13-DEC-11

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