| Module Title |
Design and Operation of Bioreactors |
| Module Code |
BTE1011 (ITS: BE322) |
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Faculty |
Biotechnology |
School |
Science & Health |
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NFQ level |
8 |
Credit Rating |
5 |
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Description
In this module the student is introduced to the main features of bioreactors including their design, control, operation and instrumentation.
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Learning Outcomes
1. Describe the main features of bioreactors and associated instrumentation
2. Demonstrate an understanding of temperature, pH and dissolved oxygen control in bioreactors
3. Demonstrate an understanding of heat and mass transfer in bioreactors, including the role of mixing, agitator design and sparger design
4. Apply simple rules for the scale-up of bioreactors
5. Communicate effectively in written or other non-oral formats, adapting to the audience profile as required.
6. Demonstrate appropriate listening skills to enhance communication.
7. Demonstrate the effective use of digital technology for communication.
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| Workload | Full time hours per semester | | Type | Hours | Description |
|---|
| Lecture | 12 | On campus lectures (bioreactors) | | Online activity | 12 | Online asynchronous lectures | | Independent Study | 16 | Completion of problem sets | | Independent Study | 4 | Viewing and study of solutions to problem sets | | Group work | 6 | Completion of team assignment (bioreactors) | | Independent Study | 75 | Study and revision |
| Total Workload: 125 |
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| Section Breakdown | | CRN | 10149 | Part of Term | Semester 1 | | Coursework | 0% | Examination Weight | 0% | | Grade Scale | 40PASS | Pass Both Elements | Y | | Resit Category | RC1 | Best Mark | N | | Module Co-ordinator | Brian Freeland | Module Teacher | Denise Harold, Paul Cahill, Paula Meleady |
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| Assessment Breakdown |
| Type | Description | % of total | Assessment Date |
|---|
| In Class Test | In-class test on bioreactor design and operation and processes | 50% | n/a | | Assignment | Team assignment (including team presentation) | 25% | n/a | | Assignment | Individual assignment on a research article related to bioprocessing and bioreactors | 25% | n/a |
| Reassessment Requirement Type |
Resit arrangements are explained by the following categories;
RC1: A resit is available for both* components of the module.
RC2: No resit is available for a 100% coursework module.
RC3: No resit is available for the coursework component where there is a coursework and summative examination element.
* ‘Both’ is used in the context of the module having a coursework/summative examination split; where the module is 100% coursework, there will also be a resit of the assessment
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Pre-requisite |
None
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Co-requisite |
None |
| Compatibles |
None |
| Incompatibles |
None |
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All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml
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Indicative Content and Learning Activities
Bioreactor construction and instrumentation
The main characteristics of bioreactors. The standard configuration. Temperature, pH and DO probes. Biomass probes and PAT.
Control of bioreactors
The feedback concept. On-off control. PI control. Controller response characteristics
Heat, mass and momentum transfer in bioreactors
Power number and Reynolds number in bioreactors. The formation and dynamics of bubbles in agitated systems. Measuring and predicting the kLa in bioreactors. Sterilization and cooling of bioreactors.
Scale-up bioreactors
Geometric similarity. Mixing times. Scale-up rules.
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Indicative Reading List
Books:
- B. Atkinson and F. Mavituna: 1991, Biochemical Engineering and Biotechnology Handbook, 2nd Ed., Macmillan, 1561590126
- P. Doran: 1995, Bioprocess Engineering Principles, P. Doran, Academic Press, London, 0122208552
- H.W. Blanch and D.S. Clark: 1996, Biochemical Engineering, Marcel Dekker, New York, 0824789490
- J.D. Bu'Lock and B. Kristiansen: 1987, Basic Biotechnology, Academic Press, London, 0121407527
- A.H.Scragg: 1991, Bioreactors in Biotechnology - A Practical Approach, E. Horwood, New York, 0130851434
- J.E. Bailey and D.F. Ollis: 1986, Biochemical Engineering Fundamentals, 2nd, McGraw-Hill, New York, 0070032122
Articles:
None |
Other Resources
None |
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