Registry
Module Specifications
Archived Version 2003 - 2004
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Module Aims
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To apply the principles of heat, mass and momentum transfer to bioprocess systems
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Learning Outcomes
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At the end of this course the student should be able to:
7 Apply the principles of fluid mechanics to characterise the rheology of fermentation broths
7 Use fundamentals of fluid mechanics to study ideal gas-liquid and liquid-liquid interactions in chemical and biological processing equipment
7 Apply the principles of heat transfer to a bioreactor system, with reference to both heat generation and removal
7 Specify typical aeration and agitation systems for common bioprocessing applications
7 Determine and predict oxygen mass transfer coefficients in bioreactors
7 Apply the principles of scale-up to the design of bioreactor systems
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Indicative Time Allowances
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Hours
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Lectures |
30
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Tutorials |
6
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Laboratories |
0
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Seminars |
0
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Independent Learning Time |
39
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Total |
75
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Placements |
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Assignments |
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NOTE
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Assume that a 5 credit module load represents approximately 75 hours' work, which includes all teaching, in-course assignments, laboratory work or other specialised training and an estimated private learning time associated with the module.
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Indicative Syllabus
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· Introduction to bioreactor systems -
principles and practices of fermentation; fermentation
organisms; basic bioreactor design
· Rheology - review of fluid rheology; experimental
viscometry of biofluids; effects of cell morphology on broth
rheology
· Bubbles and drops - bubble formation, break-up and
coalescence; bubble rise velocities; interfacial area and
hold-up in agitated and non-agitated systems; behaviour of
bubbles in beverages; drop dispersion
· Aeration and agitation - achieving mixing and mass
transfer in bioreactors; specification of equipment; flow
regimes; power requirements
· Oxygen mass transfer in bioreactors - microbial
oxygen demands; methods for the determination of mass
transfer coefficients; mass transfer correlations
· Scale-up of stirred tank bioreactors - principle of
similarity; criteria for scale-up in biological systems
· Heat generation and heat transfer in bioreactors -
sources of heat generation; heat removal; specification of
heating/cooling systems; heat transfer coefficients in
agitated systems
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Assessment | Continuous Assessment | 0% | Examination Weight | 100% |
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Indicative Reading List
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Essential:
7 Biochemical Engineering and Biotechnology Handbook, B. Atkinson and F. Mavituna (Macmillan, 1991)
7 Bioprocess Engineering Principles, P. Doran (Academic Press, 1995)
7 Biochemical Engineering, H.W. Blanch and D.S. Clark (Marcel Dekker, 1996)
Supplementary:
7 Basic Biotechnology, J. Bu'lock and B. Kristiansen (Academic Press, 1987)
7 Bioreactors in Biotechnology - A Practical Approach, A.H. Scragg (Ellis Horwood, 1991)
7 Biochemical Engineering Fundamentals, J. Bailey and D. Ollis (McGraw Hill, 1986)
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Programme or List of Programmes
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BT | BSc in Biotechnology |
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