|
|
|
Module Aims
|
7 To provide a detailed understanding of the theory and applications of advanced aspects of immunology.
7 To provide an insight into the advantages and limitations of immunoanalytical approaches in clinical, industrial and other situations.
|
|
Learning Outcomes
|
Students should gain a:
7 Detailed knowledge of the cellular events involved in antigen recognition and antibody production.
7 Understanding of molecular factors that confer immunogenicity to antigens.
7 Detailed knowledge of the methods used to produce antibodies and their appropriate applications.
7 Understanding of methods used to produce antibody-based conjugates and their applications.
7 Knowledge of advanced aspects of immunoanalysis including cytometry, immuno-cytochemistry, sensors and antibody-based targeting of ligands.
|
|
Indicative Time Allowances
|
|
|
Hours
|
|
Lectures |
24
|
|
Tutorials |
4
|
|
Laboratories |
0
|
|
Seminars |
2
|
|
Independent Learning Time |
45
|
|
|
|
|
Total |
75
|
|
Placements |
|
|
Assignments |
|
|
|
NOTE
|
Assume that a 5 credit module load represents approximately 75 hours' work, which includes all teaching, in-course assignments, laboratory work or other specialised training and an estimated private learning time associated with the module.
|
|
Indicative Syllabus
|
|
¿ The Process of antibody production at the cellular level.
¿ Intrinsic and extrinsic factors that influence
antigenicity.
¿ Detailed account of B-cell stimulation.
¿ Antigen processing within the B-cell.
¿ The function and structure of the major histocompatibility
antigens (MHC).
¿ The interaction of B-cells and T-cells.
¿ Genetic control of the immune response.
¿ Latest advances in understanding self, and non-self
immune responses.
¿ B-cell and T-cell repertoires.
¿ Methods of antibody production (in detail) including
polyclonal, monoclonal, bifunctional, multifunctional,
genetic methods and production of antibody-derived
fragments.
¿ Genetics of antibody production.
¿ Reshaped, chimaeric and human antibodies-production and
applications.
¿ Use of antibodies in cancer including diagnosis,imaging
and treatment.
¿ Production and application of conjugates used for
the generation of antibodies and in immunoanalysis.
¿ Detailed account of immunocytochemistry and
its applications.
¿ Flow cytometry - applications particularly related
to use of antibodies.
¿ Immunosensors and their applications.
|
| Assessment | | Continuous Assessment | 0% | Examination Weight | 100% |
|
|
Indicative Reading List
|
|
Essential:
7 Immunology by I. Roitt (Churchill Livingstone, 2002).
7 Special Notes prepared by Lecturers.
7 Selected recent scientific research articles.
Supplementary:
7 Enzyme Immunoassay by P. Tijssen (Elsevier, 1985).
7 Immunology by I. Roitt, J. Brostoff, D. Male (Gower, 2001).
|
|
|
|
Programme or List of Programmes
|
| BSSA | Study Abroad (DCU Business School) |
| BSSAO | Study Abroad (DCU Business School) |
| BT | BSc in Biotechnology |
| ECSA | Study Abroad (Engineering & Computing) |
| ECSAO | Study Abroad (Engineering & Computing) |
| HMSA | Study Abroad (Humanities & Soc Science) |
| HMSAO | Study Abroad (Humanities & Soc Science) |
| SHSA | Study Abroad (Science & Health) |
| SHSAO | Study Abroad (Science & Health) |
| Archives: | |
