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Module Title |
Transport Phenomena in Bioprocess Systems
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Module Code |
BE322
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School |
School of Biotechnology
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Online Module Resources
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| Module Co-ordinator | Dr Enrico Marsili | Office Number | X205 |
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Level |
3
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Credit Rating |
5
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Pre-requisite |
None
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Co-requisite |
None
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Module Aims
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To apply the principles of heat, mass and momentum transfer to bioprocess systems
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Learning Outcomes
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At the end of this course the student should be able to:·
- Apply the principles of fluid mechanics to characterise the rheology of fermentation broths·
- Use fundamentals of fluid mechanics to study ideal gas-liquid and liquid-liquid interactions in chemical and biological processing equipment·
- Apply the principles of heat transfer to a bioreactor system, with reference to both heat generation and removal·
- Specify typical aeration and agitation systems for common bioprocessing applications·
- Determine and predict oxygen mass transfer coefficients in bioreactors·
- Apply the principles of scale-up to the design of bioreactor systems
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Indicative Time Allowances
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Hours
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Lectures |
30
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Tutorials |
6
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Laboratories |
0
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Seminars |
0
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Independent Learning Time |
39
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Total |
75
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Placements |
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Assignments |
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NOTE
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Assume that a 5 credit module load represents approximately 75 hours' work, which includes all teaching, in-course assignments, laboratory work or other specialised training and an estimated private learning time associated with the module.
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Indicative Syllabus
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- Introduction to bioreactor systems - principles and practices of fermentation; fermentation organisms; basic bioreactor design· Rheology - review of fluid rheology; experimental viscometry of biofluids; effects of cell morphology on broth rheology·
- Bubbles and drops - bubble formation, break-up and coalescence; bubble rise velocities; interfacial area and hold-up in agitated and non-agitated systems; behaviour of bubbles in beverages; drop dispersion·
- Aeration and agitation - achieving mixing and mass transfer in bioreactors; specification of equipment; flow regimes; power requirements·
- Oxygen mass transfer in bioreactors - microbial oxygen demands; methods for the determination of mass transfer coefficients; mass transfer correlations· Scale-up of stirred tank bioreactors - principle of similarity; criteria for scale-up in biological systems· Heat generation and heat transfer in bioreactors - sources of heat generation; heat removal; specification of heating/cooling systems; heat transfer coefficients in agitated systems
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| Assessment | | Continuous Assessment | 0% | Examination Weight | 100% |
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Indicative Reading List
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Essential:
- Biochemical Engineering and Biotechnology Handbook, B. Atkinson and F. Mavituna (Macmillan, 1991)·
- Bioprocess Engineering Principles, P. Doran (Academic Press, 1995)·
- Biochemical Engineering, H.W. Blanch and D.S. Clark (Marcel Dekker, 1996) Supplementary:·
- Basic Biotechnology, J. Bu'lock and B. Kristiansen (Academic Press, 1987)·
- Bioreactors in Biotechnology - A Practical Approach, A.H. Scragg (Ellis Horwood, 1991)·
- Biochemical Engineering Fundamentals, J. Bailey and D. Ollis (McGraw Hill, 1986)
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Programme or List of Programmes
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| BSSA | Study Abroad (DCU Business School) |
| BSSAO | Study Abroad (DCU Business School) |
| BT | BSc in Biotechnology |
| ECSA | Study Abroad (Engineering & Computing) |
| ECSAO | Study Abroad (Engineering & Computing) |
| HMSA | Study Abroad (Humanities & Soc Science) |
| HMSAO | Study Abroad (Humanities & Soc Science) |
| SHSA | Study Abroad (Science & Health) |
| SHSAO | Study Abroad (Science & Health) |
| Archives: | |
