Module Title |
Immunology and Immunoanalysis
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Module Code |
BE433
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School |
School of Biotechnology
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Online Module Resources
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Module Co-ordinator | Dr. Paul Leonard | Office Number | A210 |
Level |
4
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Credit Rating |
5
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Pre-requisite |
None
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Co-requisite |
None
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Module Aims
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- To provide a detailed understanding of the theory and applications of advanced aspects of immunology.
- To provide an insight into the advantages and limitations of immunoanalytical approaches in clinical, industrial and other situations.
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Learning Outcomes
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Students should gain a:
- Detailed knowledge of the cellular events involved in antigen recognition and antibody production.
- Understanding of molecular factors that confer immunogenicity to antigens.
- Detailed knowledge of the methods used to produce antibodies and their appropriate applications.
- Understanding of methods used to produce antibody-based conjugates and their applications.
- Knowledge of advanced aspects of immunoanalysis including cytometry, immuno-cytochemistry, sensors and antibody-based targeting of ligands.
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Indicative Time Allowances
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Hours
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Lectures |
24
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Tutorials |
4
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Laboratories |
0
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Seminars |
2
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Independent Learning Time |
45
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Total |
75
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Placements |
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Assignments |
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NOTE
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Assume that a 5 credit module load represents approximately 75 hours' work, which includes all teaching, in-course assignments, laboratory work or other specialised training and an estimated private learning time associated with the module.
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Indicative Syllabus
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The Process of antibody production at the cellular level.
Intrinsic and extrinsic factors that influence antigenicity.
Detailed account of B-cell stimulation.
Antigen processing within the B-cell.
The function and structure of the major histocompatibility antigens (MHC).
The interaction of B-cells and T-cells.
- Genetic control of the immune response.
- Latest advances in understanding self, and non-self immune responses.
- B-cell and T-cell repertoires.
- Methods of antibody production (in detail) including polyclonal, monoclonal, bifunctional, multifunctional, genetic methods and production of antibody-derived fragments.
- Genetics of antibody production.
- Reshaped, chimaeric and human antibodies-production and applications.
- Use of antibodies in cancer including diagnosis,imaging and treatment.
- Production and application of conjugates used for the generation of antibodies and in immunoanalysis.
- Detailed account of immunocytochemistry and its applications.
- Flow cytometry - applications particularly related to use of antibodies.
- Immunosensors and their applications.
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Assessment | Continuous Assessment | 0% | Examination Weight | 100% |
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Indicative Reading List
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Essential:
- Immunology by I. Roitt (Churchill Livingstone, 2002).
- Special Notes prepared by Lecturers.
- Selected recent scientific research articles.Supplementary:
- Enzyme Immunoassay by P. Tijssen (Elsevier, 1985).
- Immunology by I. Roitt, J. Brostoff, D. Male (Gower, 2001).
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Programme or List of Programmes
|
BSSA | Study Abroad (DCU Business School) |
BSSAO | Study Abroad (DCU Business School) |
BT | BSc in Biotechnology |
ECSA | Study Abroad (Engineering & Computing) |
ECSAO | Study Abroad (Engineering & Computing) |
GCB | BSc in Genetics & Cell Biology |
HMSA | Study Abroad (Humanities & Soc Science) |
HMSAO | Study Abroad (Humanities & Soc Science) |
SHSA | Study Abroad (Science & Health) |
SHSAO | Study Abroad (Science & Health) |
Archives: | |