Module Specifications.
Current Academic Year 2024 - 2025
All Module information is indicative, and this portal is an interim interface pending the full upgrade of Coursebuilder and subsequent integration to the new DCU Student Information System (DCU Key).
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Date posted: September 2024 No Banner module data is available
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Repeat examination Array |
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Description This module will introduce students to the field of comparative genomics and it's many applications and to the field of developmental biology with a focus on the molecular processes underlying Eukaryotic development. | |||||||||||||||||||||||||||||||||||||||||||
Learning Outcomes 1. Discuss the basic concepts of comparative genomics and developmental biology from both a computational and cellular perspective 2. Describe the process of analysing biological sequence data from databases to statistical methods for analysing/assessing data signal 3. Discuss concepts in molecular evolution 4. Applications of comparative genomics: across species, within species and within individuals 5. Consideration of the concepts development and the main model organisms used in this field. 6. Demonstrate an understanding of cell differentiation and it's reversibility in different contexts. 7. Knowledge of the physiology of human development and current research to investigate its molecular aspects. 8. An understanding and being able to describe the molecular detail of Drosophila early development. 9. Knowledge of specific laboratory techniques that have relevance of investigation of development processes. | |||||||||||||||||||||||||||||||||||||||||||
All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml |
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Indicative Content and Learning Activities
Comparative GenomicsIntroduction to Comparative Genomics, key concepts including homology, orthology and paralogy. Major comparative genomic methods will be dealt with in detail, including pairwise and multiple alignment methodologies, probability and statistical analysis of sequence alignments, databases and mining, phylogeny reconstruction. Applications of comparative genomics across species, within species and within individuals will be explored.Developmental BiologyA brief history of developmental biology. Early key experiments and milestones. Introduction of model organisms such as Xenopus, zebrafish, chick,mouse, Drosophila and C. elegans. Basic stages of development:comparison of model organisms. Focus on Drosophila lifecycle and development. Drosophila developmental genetics- establishment of body plan: anterior-posterior axis, dorsal-ventral axis. | |||||||||||||||||||||||||||||||||||||||||||
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Indicative Reading List
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Other Resources None | |||||||||||||||||||||||||||||||||||||||||||