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Module Specifications

Archived Version 2008 - 2009

Module Title	Comparative Genomics & Developmental Biology
Module Code	BE310
School	School of Biotechnology
Online Module Resources
Module Co-ordinator	Dr Mary O'Connell	Office Number	X215
Level	3	Credit Rating	5
Pre-requisite	None
Co-requisite	None

Module Aims

The Comparative Genomics section of this module will introduce students to the field of comparative genomics and its many applications. This module will follow the flow of comparative genomic analyses from biological database through to statistical and mathematical models of analyses of data from sequence databanks and micro. Arrays with the aim of understanding the patterns and signals present.

The Developmental Biology section of this module aims to introduce the basic concept of how a single fertilised egg gives rise to a multicellular organism. The module will focus on the general principles of development identified in a few key model organisms and how these principles can be applied to other organisms in a bid to understand animal development.

Learning Outcomes

The Students will learn the importance of comparative genomics and its applications to molecular biology and genetics. Student will have a clear understanding of: Theory and history of comparative genomics, major comparative genomic methods including:

sequence alignment - both pairwise and multiple
probability and statistical analysis of sequence alignments
sequence similarity searching
phylogeny reconstruction; and microArray analysis - statistical and clustering methods

Students will learn why a small number of model organisms are used to study development due to their convenience amenable to experimental manipulation or genetic analysis. An overview of the basic stages of development: fertilisation, cleavage, gastrulation, neurulation and organogenesis.

The following key developmental concepts will be covered:

cell fate
determination and specification
genetic control and gradients (morphogens)
pattern formation - body plan, polarity, germ layers, morphogenesis, cell differentiation; and the role of maternal factors

Indicative Time Allowances
	Hours
Lectures	24
Tutorials
Laboratories
Seminars	51
Independent Learning Time	0

Total	75
Placements
Assignments

NOTE

Assume that a 5 credit module load represents approximately 75 hours' work, which includes all teaching, in-course assignments, laboratory work or other specialised training and an estimated private learning time associated with the module.

Indicative Syllabus

Introduction to Comparative Genomics, key concepts including homology, orthology and paralogy.
Major comparative genomic methods will be dealt with in detail, including Pairwise and multiple alignment methodologies, Probability and Statistical Analysis of Sequence alignments, Databases and mining, Phylogeny reconstruction and problem solving, MicroArray Analysis statistics and clustering methodologies.
A brief history of developmental biology.
Early key experiments and milestones.
Introduction of model organisms such as Xenopus, zebrafish, chick,mouse, Drosophila andC. elegans.
Basic stages of development: comparison of model organisms.
Focus on Drosophila lifecycle and development.
Drosophila developmental genetics- establishmentof body plan: anterior-posterior axis, dorsal-ventral axis.