Registry

Module Specifications

Archived Version 2005 - 2006

Module Title	Microbiology and Genetics II
Module Code	BE233
School	School of Biotechnology
Online Module Resources
Level	2	Credit Rating	5
Pre-requisite	None
Co-requisite	None

Module Aims

To develop an understanding of the genetic complexity of biological systemsTo inform students on the current state of understanding of genetic structure and function in prokaryotes and eukaryotesTo provide an overview of genetic mechanisms, heredity and evolution

Learning Outcomes

A knowledge of bacterial and bacteriophage genetics, of genetic structure and organisation in eukaryotes, of population genetics and evolution, will be gained. A conceptual framework will be established to enable the student to understand the field of genetics and genetic technologies.

Indicative Time Allowances
	Hours
Lectures	36
Tutorials	2
Laboratories
Seminars
Independent Learning Time	37

Total	75
Placements
Assignments

NOTE

Assume that a 5 credit module load represents approximately 75 hours' work, which includes all teaching, in-course assignments, laboratory work or other specialised training and an estimated private learning time associated with the module.

Indicative Syllabus

Prokaryotic Genetics Genomes -definition, size and complexity, circular and linear chromosomes, plasmids Mutation, the basis for diversity -point mutations, deletions, frameshifting, insertions, inversions, phasevariation, reversion, conditional lethal mutants, suppression, complementation, genotype and phenotype, mutagenesis, mutant selection,auxotrophy, the Ames test Recombination and repair -homologous, site specific and illegitimate recombination, transposition, IS elements, transposons, integrons Bacteriophage genetics -bacteriophage l, lysogenic and lytic life cycles, control of lysogeny, other bacteriophages, M13, T4, Gene transfer in bacteria -transformation, discovery, mechanisms, transduction, specialised and generalised, conjugation, the F factor, Hfr and F prime strains, mapping the Escherichia coli genome, R factors, antibiotic resistance, conjugativetransposons, plasmid mobilisationGenetic organisation and regulation -operons and regulons, regulators, repression and activation, the lactose and arabinose operons, post transcriptional regulation, global regulators, quorum sensing Example of genetic structure and function in bacteria -the virulence of Vibrio cholerae Eukaryotic Genetics Heredity - Historical Prospective, Mendelian Genetics, Extensions of Mendelian GeneticsQuantitative Genetics, Linkage Crossing Over and Mapping in EukaryotesSex Determination and Sex Chromosomes, Extrachromosomal inheritanceChromosome Mutations: Variation in Chromosome Number and arrangement. Genetics of Organisms and Populations - Developmental Genetics, Genetics and Cancer, Genetics and Immunity - Genetics and Behaviour, Population Genetics, Evolution.