Registry
Module Specifications
Archived Version 2018 - 2019
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Description To develop an understanding of the genetic complexity of biological systems To inform students on the current state of understanding of genetic structure and function in prokaryotes and eukaryotes To provide an overview of genetic mechanisms, heredity and evolution To elaborate and differentiate gene regulatory mechanisms and evolutionary patterns in microbial genomes | |||||||||||||||||||||||||||||||||||||||||
Learning Outcomes 1. Discuss the principles of Heredity and describe the current understanding of evolutionary principles 2. Outline the concepts of developmental genetics and explain how a differentiated state develops from an organism s genome. 3. Define the genetic complexity of biological systems and the current state of understanding of genetic structure and function in prokaryotes and eukaryotes 4. Differentiate gene regulatory mechanisms and evolutionary patterns in microbial genomes | |||||||||||||||||||||||||||||||||||||||||
All module information is indicative and subject to change. For further information,students are advised to refer to the University's Marks and Standards and Programme Specific Regulations at: http://www.dcu.ie/registry/examinations/index.shtml |
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Indicative Content and
Learning Activities Prokaryotic Genetics1. Prokaryotic genomes types, sizes, complexity, circular/linear chromosomes, plasmids 2. Gram-negative bacterial genomes: Escherichia coli 3. Gram-positive bacterial genomes: Staphylococcus aureus 4. Mutation types: single-nucleotide, insertions, deletions, inversions, frameshifts, translocations, complex cases 5. Mutation testing: phase-variation, reversion, conditional lethal mutants, suppression, complementation, mutagenesis, mutant selection, auxotrophy, the Ames test 6. Recombination and DNA repair-homologous, site specific and illegitimate recombination 7. Transposable Elements and transposition, IS elements, transposons, integrons, conjugative transposons 8. Bacteriophages, lysogenic and lytic life cycles, control of lysogeny, other bacteriophages, M13, T4 9. Transformation: discovery and mechanisms 10. Transduction: specialised and generalised 11. Plasmids, F and R factors, antimicrobial resistance 12. Conjugation, plasmid mobilisation, chromosome mobilisation 13. Plasmid Replication 14. Gene regulation: operons and regulons, regulators, repression and activation 15. Gene regulation: the lactose and arabinose operons, 16. Post-transcriptional regulation, two component systems, ECF sigma factors, quorum sensingEukaryotic GeneticsHeredity - Historical Prospective, Mendelian Genetics, Extensions of Mendelian Genetics Quantitative Genetics, Linkage Crossing Over and Mapping in Eukaryotes, Mitosis and Meiosis, Sex Determination and Sex Chromosomes, Extrachromosomal inheritance, Developmental Genetics, Genetics and Behaviour, Population Genetics, Evolution. Speciation | |||||||||||||||||||||||||||||||||||||||||
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Indicative Reading List | |||||||||||||||||||||||||||||||||||||||||
Other Resources None | |||||||||||||||||||||||||||||||||||||||||
Programme or List of Programmes | |||||||||||||||||||||||||||||||||||||||||
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